ERI1 (D298) polyclonal antibody
Product Specifications
Background
Helicase with RNase motif, more commonly designated Dicer, cleaves doublestranded RNA (dsRNA) in the RNA interference and small temporal RNA (stRNA) pathways, producing active small RNA components (siRNAs) which target the destruction of RNA and repress gene expression. Human Dicer cleaves dsRNA independent of ATP. The 3’-5’ exonuclease ERI-1, also known as Protein 3’hExo, degrades Histone mRNA after replication and may be involved in the regulation of RNA interference. ERI-1 has a high affinity for the stem-loop structure of replication-dependent Histone pre-mRNAs. It requires the 5’-ACCCA-3’ sequence present in stem-loop structure. ERI-1 and a stemloop binding protein (SLBP) target opposite faces of a unique highly conserved stem-loop RNA scaffold towards the 3’ end of Histone mRNA.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
3'EXO; THEX1; HEXO; Eri-1 homolog; 3'-5' exoribonuclease 1
Swiss Prot
Q8IV48
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 266-318 of Human ERI1.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 42 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
ERI1 (D298) polyclonal antibody detects endogenous levels of ERI1 protein.
Applications Notes
Western blot (WB) analysis of ERI1 pAb at 1:500 dilution Lane1:SGC7901 whole cell lysate (40ug) Lane2:A549 whole cell lysate (40ug) Lane3:U-87MG whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
Curated Selection
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