VDR (N204) polyclonal antibody
Product Specifications
Background
The vitamin D receptor (VDR), also known as the calcitriol receptor, and also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors. Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or trans-repression of specific gene products.It is an intracellular hormone receptor that specifically binds 1,25 (OH) 2D3 and mediates its effects. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer.
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Vitamin D3 receptor; VDR; 1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1; NR1I1
Swiss Prot
P11473
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 161-210 of Human VDR.
Conjugation
Unconjugated
Related Pathways
Nuclear Receptor Signaling
Applications
WB IHC IF
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 43, 55 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
VDR (N204) polyclonal antibody detects endogenous levels of VDR protein
Applications Notes
Western blot (WB) analysis of VDR (N204) pAb at 1:500 dilution Lane1:K562 whole cell lysate (40ug) Lane2:HCT116 whole cell lysate (40ug) Lane3:3T3-L1 whole cell lysate (40ug) Lane4:The Kidney tissue lysate of Rat (40ug)
Host or Source
Rabbit
CAS Number
9007-83-4
Available Sizes
Curated Selection
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