CNPase (A108) polyclonal antibody
Product Specifications
Background
CNPase (2',3'-Cyclic Nucleotide 3'-Phosphodiesterase) exists in two forms: 46kDa (CNP1) and 48kDa (CNP2) . It is expressed at high levels by oligodendrocytes in the central nervous system and by Schwann cells in the peripheral nervous system and is virtual absent in other cell types. CNPase activity is decreased in demyelinating diseases such as multiple sclerosis. CNPase gene is localized to chromosome 17q21, very near the BRCA 1 familial breast cancer gene.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
2',3'-cyclic-nucleotide 3'-phosphodiesterase; CNP
Swiss Prot
P09543
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 61-110 of Human CNPase.
Conjugation
Unconjugated
Related Pathways
Neuronal and Glial Cell Marker Atlas
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 47 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CNPase (A108) polyclonal antibody detects endogenous levels of CNPase protein.
Applications Notes
Western blot (WB) analysis of CNP pAb at 1:1000 dilution Lane1:The Brain tissue lysate of Mouse (40ug) Lane2:PC12 whole cell lysate (40ug) Lane3:CT-26 whole cell lysate (40ug) Lane4:SGC7901 whole cell lysate (40ug) Lane5:K562 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
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