PSG1 polyclonal antibody
Product Specifications
Background
Pregnancy specific glycoprotein 1 (PSG1), also designated CD66f, is a member of the PSG family, a group of closely related secreted glycoproteins that are highly expressed in fetal placental syncytiotrophoblast cells. The members of the PSG protein family all have a characteristic N-terminal domain that is homologous to the immunoglobulin variable region. PSGs become detectable in serum during the first two to three weeks of pregnancy and increase as the pregnancy progresses, eventually representing the most abundant fetal protein in the maternal blood at term. PSGs function to stimulate secretion of TH2-type cytokines from monocytes, and they may also modulate the maternal immune system during pregnancy, thereby protecting the semi-allotypic fetus from rejection. PSGs are commonly expressed in trophoblast tumors. 11 human PSG proteins (PSG1-PSG11) have been described.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Pregnancy-specific beta-1-glycoprotein 1; PS-beta-G-1; PSBG-1; Pregnancy-specific glycoprotein 1; CD66 antigen-like family member F; Fetal liver non-specific cross-reactive antigen 1/2; FL-NCA-1/2; PSG95; Pregnancy-specific beta-1 glycoprotein C/D; PS-beta-C/D; CD66f; PSG1; B1G1; PSBG1; PSGGA
Swiss Prot
P11464
Reactivity
Human
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 180-419 of human PSG1
Conjugation
Unconjugated
Applications
WB IHC IF
Dilution
WB: 1:500 - 1:2000 IHC:1:50 - 1:100 IF:1:50 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 55-72 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recombinant fusion protein containing a sequence corresponding to amino acids 180-419 of human PSG1
Applications Notes
Western blot analysis of extracts of various cell lines, using PSG1 antibody at 1:1000 dilution. Lysates/proteins: 40ug per lane. Exposure time: 90s.
Host or Source
Rabbit
Available Sizes
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