PLSCR1 polyclonal antibody
Product Specifications
Background
The calcium-dependent plasma membrane protein phospholipid scramblase 1 (PLSCR1) contributes to the transbilayer movement of phosphatidylserine and other membrane phospholipids upon influx of calcium into the cytosol. This movement results in plasma membrane phospholipid remodelling and surface exposure of phosphatidylserine in injured or apoptotic cells, which leads to cell death. Interferons and other cytokines induce expression of PLSCR1, implying that PLSCR1 also functions in cytokine signaling pathways. EGF stilmulation results in tyrosine phosphorylation of PLSCR1 on tyrosines 69 and 74, which allows it to interact with Shc, and thereby connecting Src kinase activation to stimulation of the EGF receptor.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Phospholipid scramblase 1; PL scramblase 1; Ca (2+) -dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase; MmTRA1b
Swiss Prot
O15162
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human PLSCR1.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 40 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
PLSCR1 polyclonal antibody detects endogenous levels of PLSCR1 protein.
Applications Notes
Western blot (WB) analysis of PLSCR1 pAb at 1:500 dilution Lane1:H9C2 whole cell lysate (40ug) Lane2:CT26 whole cell lysate (40ug) Lane3:HepG2 whole cell lysate (40ug) Lane4:HCT116 whole cell lysate (40ug) Lane5:A549 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
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