Human IgG1
Product Specifications
Background
Native IgG1 from healthy human plasma.Purified from plasma of patients with healthy human producing IgG1 with kappa light chains. IgG is a monomeric immunoglobulin, built of two heavy chains gamma and two light chains. Each molecule has two antigen binding sites. This is the most abundant immunoglobulin and is approximately equally distributed in blood and in tissue liquids, constituting 75% of serum immunoglobulins in humans. This is the only isotype that can pass through the human placenta, thereby providing protection to the fetus in its first weeks of life before its own immune system has developed. It can bind to many kinds of pathogens, for example viruses, bacteria, and fungi, and protects the body against them by complement activation (classic pathway), opsonization for phagocytosis and neutralisation of their toxins. There are 4 subclasses: IgG1 (66%), IgG2 (23%), IgG3 (7%) and IgG4 (4%) .
Structure Composition
PBS, pH7.4
Swiss Prot
P01857
Reactivity
Native
Immunogen
Human IgG1
Conjugation
Unconjugated
Dilution
Immunogen SDS-PAGE
Purity
The antibody was affinity-purified from healthy human by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
100ug/1mg
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Full length protein
Applications Notes
Single arc by immunoelectrophoresis against antiserum to whole human sera and human κ free and bound light chain. Note: Variables associated with assay conditions will dictate the proper working dilution.
Host or Source
Human
Available Sizes
Curated Selection
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