SCML2 polyclonal antibody
Product Specifications
Background
In Drosophila, the Polycomb (PcG) gene family encodes chromatin proteins that are required for the repression of homeotic loci in embryonic development. PcG proteins work in conjunction with the trithorax-group (trxG), which activate homeobox gene expression during embryonic development. SCM (sex comb on midleg) is an important Drosophila PcG protein involved in transcriptional repression. SCML2 (sex comb on midleg-like 2) is a human homolog of this Drosophila protein. SCML2 is a ubiquitously expressed protein with predominant expression in placenta, testis and thymus. Upon DNA damage, SCML2 may be phosphorylated by ATR or ATM. Due to alternative splicing, two isoforms exist for this protein.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.
Product Name Alternative
Sex comb on midleg-like protein 2; SCML2
Swiss Prot
Q9UQR0
Reactivity
Human
Immunogen
Synthetic peptide, corresponding to Human SCML2.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1000
Purity
The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 77,93 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
SCML2 polyclonal antibody detects endogenous levels of SCML2 protein.
Applications Notes
Western blot (WB) analysis of SCML2 polyclonal antibody at 1:500 dilution LaneA:HEK293T whole cell lysate LaneB:K562 whole cell lysate LaneC:A549 whole cell lysate LaneD:H1792 whole cell lysate
Host or Source
Rabbit
Available Sizes
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