SRPK3 polyclonal antibody

Product Specifications

Background

Arginine/serine-rich (RS) domain-containing proteins and their phosphorylation by specific protein kinases constitute control circuits to regulate both constitutive and alternative pre-mRNA splicing and coordinate splicing with transcription in cells. Two SR protein-specific kinases (SRPK, also designated SFRSK), SRPK1 and SRPK2, are highly specific for the phosphorylation of these RS proteins, thereby contributing to splicing regulation. SRPK1 plays a role in the condensation of sperm chromatin. SRPK2 has a stringent preference for SR dipeptides and contains a proline-rich sequence at its amino terminus. Both SRPK1 and SRPK2 are highly expresed in testes. SRPK1 is found exclusively in pancreas and SRPK2 is found exclusively in brain and lung. SRPK3 is expressed in the heart and in skeletal muscle.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Product Name Alternative

SRSF protein kinase 3; Muscle-specific serine kinase 1; MSSK-1; Serine/arginine-rich protein-specific kinase 3; SR-protein-specific kinase 3; Serine/threonine-protein kinase 23; SRPK3; MSSK1; STK23

Swiss Prot

Q9UPE1

Reactivity

Human, Rat, Mouse

Immunogen

Synthetic peptide, corresponding to Human SRPK3.

Conjugation

Unconjugated

Applications

Dilution

WB:1:500~1:1000

Purity

The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 59 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

SRPK3 polyclonal antibody detects endogenous levels of SRPK3 protein.

Applications Notes

Western blot (WB) analysis of SRPK3 polyclonal antibody at 1:500 dilution LaneA:PC3 whole cell lysate LaneB:H1792 whole cell lysate LaneC:PC12 whole cell lysate LaneD:The heart tissue lysate of Mouse