XPLN polyclonal antibody
Product Specifications
Background
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.
Product Name Alternative
GEF3; STA3; XPLN
Swiss Prot
Q9NR81
Reactivity
Human
Immunogen
Synthetic peptide, corresponding to Human XPLN.
Conjugation
Unconjugated
Applications
WB IHC ICC
Dilution
WB:1:500~1:1000 IHC:1:50~1:200 ICC:1:50~1:200
Purity
The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 55 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
XPLN polyclonal antibody detects endogenous levels of XPLN protein.
Applications Notes
Western blot analysis of extracts of human brain line, using XPLN polyclonal antibody.
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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