MOV10L1 polyclonal antibody
Product Specifications
Background
MOV10 is a RNA helicase that is required for RNA-mediated gene silencing by RISC (RNA-induced silencing complex) . Significantly, MOV10 is also required for the transcription and replication of the human hepatitis delta virus, also known as hepatitis D. Belonging to the same family as MOV10, MOV10L1 (moloney leukemia virus 10-like protein 1) is a 1,211 amino acid RNA helicase that is expressed as three isoforms. Interestingly, isoform 1 is expressed exclusively in testis and isoform 2 is specifically expressed in cardiac myocytes. Isoform 1 may play a role in male germ cell development, isoform 2 has been shown to potentiate phenylephrine-induced hypertrophic response in cardiomyocytes. Each isoform contains a RNA interaction motif, ATP binding site and helicase motif through which it carries out its function.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.
Product Name Alternative
RNA helicase Mov10l1; Moloney leukemia virus 10-like protein 1; MOV10-like protein 1; MOV10L1
Swiss Prot
Q9BXT6
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide, corresponding to Human MOV10L1.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB:1:500~1:1000 IHC:1:50~1:200
Purity
The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 135 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
MOV10L1 polyclonal antibody detects endogenous levels of MOV10L1 protein.
Applications Notes
Western blot (WB) analysis of MOV10L1 polyclonal antibody at 1:500 dilution LaneA:The testis tissue lysate of Rat LaneB:The testis tissue lysate of Mouse
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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