POTEG polyclonal antibody

Product Specifications

Background

POTE ankyrin domain family, member G (poteg) belongs to POTE family. The POTE family is composed of many proteins which are very closely related and expressed in prostate, ovary, testis, and placenta. Some POTE paralogs are related with some cancers. Here we showed that down‐regulation of POTEG was detected in about 60% primary esophageal squamous cell carcinoma (ESCC) tumor tissues. Clinical association studies determined that POTEG down‐regulation was significantly correlated with tumor differentiation, lymph nodes metastasis and TNM staging. Kaplan‐Meier analysis determined that POTEG down‐regulation was associated with poorer clinical outcomes of ESCC patients (P = 0.026) . Functional studies showed that POTEG overexpression could suppress tumor cell growth and metastasis capacity in vitro and in vivo. Molecular analyses revealed that POTEG downregulated CDKs, leading to subsequent inhibition of Rb phosphorylation, and consequently arrested Cell Cycle at G1/S Checkpoint.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Product Name Alternative

POTE ankyrin domain family member G; ANKRD26-like family C member 2; Prostate, ovary, testis-expressed protein on chromosome 14; POTE-14; POTEG; A26C2; POTE14

Swiss Prot

Q6S5H5; Q6S545; A6NI47

Reactivity

Human, Rat, Mouse

Immunogen

Synthetic peptide, corresponding to Human POTEG.

Conjugation

Unconjugated

Applications

WB IHC

Dilution

WB:1:500~1:1000 IHC:1:50~1:200

Purity

The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 58,54 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

POTEG polyclonal antibody detects endogenous levels of POTEG protein.

Applications Notes

Western blot (WB) analysis of POTEG polyclonal antibody at 1:500 dilution LaneA:A549 whole cell lysate LaneB:The testis tissue lysate of Mouse LaneC:The testis tissue lysate of Rat LaneD:The brain tissue lysate of Mouse