PNPT1 polyclonal antibody

Mitochondrial polyribonucleotide nucleotidyltransferase, also designated 3'-5' RNA exonuclease, OLD35, PNPase or PNPT1, is an evolutionaly conserved protein in which the mouse protein shares 90% identity with the human version. PNPase participates in mRNA degradation and hydrolyzes single-stranded ribonucleotides in the 3' to 5' direction. PNPase forms homotrimers and is upregulated in response to interferon-β induction. The N-terminus of PNPase contains a putative mitochondrial targeting sequence; mutation analysis confirms that N-terminal sequences of PNPase target the protein to the mitochondria. Endogenous PNPase also co-localizes with a mitochondrial marker protein in HeLa cells.

Polyribonucleotide nucleotidyltransferase 1, mitochondrial; 3'-5' RNA exonuclease OLD35; PNPase old-35; Polynucleotide phosphorylase 1; PNPase 1; Polynucleotide phosphorylase-like protein; PNPT1; PNPASE

Western blot (WB) analysis of PNPT1 polyclonal antibody at 1:500 dilution LaneA:PC12 whole cell lysate LaneB:MEF whole cell lysate LaneC:A549 whole cell lysate LaneD:L02 whole cell lysate LaneE:HCT116 whole cell lysate