Nectin 4 polyclonal antibody
Product Specifications
Background
Nectin-4/Poliovirus Receptor-Like 4 (PVRL4) is a type-I transmembrane glycoprotein that belongs to the immunoglobulin superfamily and promotes cell-cell adhesion by serving as a major component of adherens junctions. The extracellular domain of Nectin-4, which contains an Ig variable-like domain (V) and two Ig constant-like domains (C), mediates binding to the measles virus and to neighboring cells through trans heterophilic interactions with Nectin-1. Unlike other nectin family members, which are widely expressed in adult tissues, Nectin-4 expression in humans is largely restricted to the placenta. Research studies have demostrated that Nectin-4 is overexpressed in a variety of human solid tumors of the pancreas, breast, lung, and ovary. Due to its restricted expression pattern in normal human tissues, Nectin-4 may serve as a novel diagnostic and therapeutic target for a variety of human tumors.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.
Product Name Alternative
Nectin-4; Ig superfamily receptor LNIR; Nectin cell adhesion molecule 4; Poliovirus receptor-related protein 4; Processed poliovirus receptor-related protein 4; NECTIN4; LNIR; PRR4; PVRL4
Swiss Prot
Q96NY8
Reactivity
Human, Rat
Immunogen
Synthetic peptide, corresponding to Human Nectin 4.
Conjugation
Unconjugated
Applications
WB
Dilution
WB:1:500~1:1000
Purity
The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 66 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -21°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Nectin 4 polyclonal antibody detects endogenous levels of Nectin 4 protein.
Applications Notes
Western blot (WB) analysis of Nectin 4 polyclonal antibody at 1:500 dilution LaneA:Hela whole cell lysate LaneB:MCF-7 whole cell lysate LaneC:PC12 whole cell lysate
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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