Septin 3 polyclonal antibody
Product Specifications
Background
The septins are a family of GTPase enzymes, some of which are required for cytokinesis and others of which are associated with exocytosis. Members of the Septin family can form heteropolymer complexes and also play a role in the organization of new growth in organisms. The transcriptional regulation of all septins is complex, resulting in alternatively spliced variants. Septin 10, a 517 residue polypeptide which localizes to the cytoplasm and nucleus, shares closest homology to Septin 6 and Septin 8. Septin 10 is expressed ubiquitously, though most abundantly in the placenta, lung, kidney, heart, skeletal muscles, liver and various tumor cell lines. Like other Septin family members, Septin 10 displays GTP-binding and GTPase activity. Additionally, Septin 10 is potentially involved in cytokinesis. Upon maturation induced by lipopolysaccharide (LPS), dendritic cells express upregulated amounts of Septin 10.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.
Product Name Alternative
Neuronal-specific septin-3; SEPTIN3; SEP3; SEPT3
Swiss Prot
Q9UH03
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide, corresponding to Human Septin 3.
Conjugation
Unconjugated
Applications
WB
Dilution
WB:1:500~1:1000
Purity
The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 45 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Septin 3 polyclonal antibody detects endogenous levels of Septin 3 protein.
Applications Notes
Western blot (WB) analysis of Septin 3 polyclonal antibody at 1:500 dilution LaneA:The brain tissue lysate of Mouse LaneB:The brain tissue lysate of Rat LaneC:Hela whole cell lysate LaneD:The kidney tissue lysate of Mouse LaneE:The kidney tissue lysate of Rat
Host or Source
Rabbit
Available Sizes
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