Mannose Binding Protein polyclonal antibody
Product Specifications
Background
Mannose-binding lectin protein C (MBL-C), also known as mannose-binding protein C; mannose-binding lectin 2, soluble (opsonic defect) ; mannan-binding lectin; mannan-binding protein; and soluble mannose-binding lectin, initiates the lectin branch of the innate immune response by binding to the surface of potentially pathogenic microorganisms and initiating complement fixation through an N-terminal collagen-like domain. MBL-C is a key component in immune response due to its ability to directly trigger neutralization of invading microorganisms by an Ab-independent mechanism. It binds to sugars on the surface of bacterial, fungal and parasitic cells through C-terminal, Ca2+-dependent carbohydrate-recognition domains. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation. In human, two types of MBL-associated serine proteases (MASP-1 and MASP-2) and a truncated form of MASP-2, designated small MBL-associated protein (sMAP) or MAp19, complex with MBL to activate the lectin pathway of the complement system. Activated MASPs subsequently cleave and activate downstream components of the complement pathway.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.
Product Name Alternative
COLEC 1; COLEC1; Collectin-1; HSMBPC; Mannan binding lectin; Mannan binding protein; Mannan-binding protein; Mannose binding lectin (protein C) 2 soluble; Mannose binding lectin (protein C) 2, soluble (opsonic defect) ; Mannose binding lectin (protein C) 2, soluble; Mannose binding lectin 2 soluble; Mannose binding lectin 2, soluble (opsonic defect) ; Mannose binding lectin; Mannose binding lectin protein C2 soluble opsonic defect; Mannose binding protein; Mannose binding protein C; Mannose binding protein C precursor; Mannose-binding lectin; Mannose-binding protein C; MBL 2; MBL; MBL2; MBL2_HUMAN; MBL2D; MBP 1; MBP; MBP C; MBP-C; MBP1; MBPB; MBPC; MGC116832; MGC116833; Opsonic defect; protein C; Soluble mannose binding lectin
Swiss Prot
P11226
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide, corresponding to Human Mannose Binding Protein.
Conjugation
Unconjugated
Applications
WB
Dilution
WB:1:500~1:1000
Purity
The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 26 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Mannose Binding Protein polyclonal antibody detects endogenous levels of Mannose Binding protein.
Applications Notes
Western blot (WB) analysis of Mannose Binding Protein polyclonal antibody at 1:500 dilution LaneA:HepG2 whole cell lysate LaneB:Aml-12 whole cell lysate LaneC:PC12 whole cell lysate LaneD:L02 whole cell lysate
Host or Source
Rabbit
Available Sizes
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