GNL3L polyclonal antibody

Product Specifications

Background

Guanine nucleotide-binding protein-like 3-like protein, stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Product Name Alternative

Guanine nucleotide-binding protein-like 3-like protein; GNL3L

Swiss Prot

Q9NVN8

Reactivity

Human

Immunogen

Synthetic peptide, corresponding to Human GNL3L.

Conjugation

Unconjugated

Applications

WB IHC

Dilution

WB:1:500~1:1000 IHC:1:50~1:200

Purity

The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 72 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

GNL3L polyclonal antibody detects endogenous levels of GNL3L protein.

Applications Notes

Western blot (WB) analysis of GNL3L polyclonal antibody at 1:500 dilution LaneA:H1792 whole cell lysate LaneB:MCF-7 whole cell lysate

Host or Source

Rabbit

Available Sizes

Curated Selection

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