GAS8 polyclonal antibody
Product Specifications
Background
Gas8 (growth arrest-specific 8), also known as Gas11, is a 478 amino acid protein that localizes to the Golgi apparatus, as well as to the cytoplasm and the flagellar basal body, and belongs to the growth arrest-specific protein family. Expressed in liver, heart and skeletal muscle with lower levels present in lung, brain, kidney and placenta, Gas8 functions as a cytoskeletal linker that binds microtubules and is thought to play a role in axonemal and non-axonemal dynein regulation. Gas8 may also be involved in spermatozoa motility and, when defective, may be associated with infertility in males lacking gametocytes. The gene encoding Gas8 maps to a region on human chromosome 16 that is frequently deleted in breast and prostate cancer, suggesting a role for Gas8 in tumorigenesis.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.
Product Name Alternative
Dynein regulatory complex subunit 4; Growth arrest-specific protein 11; GAS-11; Growth arrest-specific protein 8; GAS-8; GAS8; DRC4; GAS11
Swiss Prot
O95995
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide, corresponding to Human GAS8.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB:1:500~1:1000 IHC:1:50~1:200
Purity
The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 56 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
GAS8 polyclonal antibody detects endogenous levels of GAS8 protein.
Applications Notes
Western blot (WB) analysis of GAS8 polyclonal antibody at 1:500 dilution LaneA:L02 whole cell lysate LaneB:The heart tissue lysate of Mouse LaneC:The heart tissue lysate of Rat
Host or Source
Rabbit
Available Sizes
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