Ubiquilin 4 polyclonal antibody

A1Up (Ataxin-1 ubiquitin-like-interacting protein), also known as UBQLN4 (ubiquilin 4), C1orf6 or UBIN, is a 601 amino acid protein that localizes to both the cytoplasm and the nucleus and is thought to associate with the endoplasmic reticulum (ER) . Expressed at high levels in kidney, pancreas, heart, brain and skeletal muscle and at lower levels in liver, lung and placenta, A1Up functions as a homodimer that binds to signal sequences on proteins that are targeted to the ER. Additionally, A1Up is thought to link Ataxin-1 with ubiquitin/proteasome pathways, possibly assisting in the Ataxin-1-associated formation of multimeric protein complexes within the nucleus. A1Up contains one ubiquitin-like domain and one UBA domain and may be phosphorylated in response to DNA damage.

Ubiquilin-4; Ataxin-1 interacting ubiquitin-like protein; A1Up; Ataxin-1 ubiquitin-like-interacting protein A1U; Connexin43-interacting protein of 75 kDa; CIP75; UBQLN4; C1orf6; CIP75; UBIN

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Western blot (WB) analysis of Ubiquilin 4 polyclonal antibody at 1:500 dilution LaneA:COS-7 whole cell lysate LaneB:HEK293T whole cell lysate LaneC:AML-12 whole cell lysate LaneD:PC12 whole cell lysate