SHANK2 polyclonal antibody
Product Specifications
Background
The SHANK family proteins, also known as proline-rich synapse-associated proteins, consist of SHANK1, SHANK2, and SHANK3. SHANK proteins act as scaffolds at the neuronal post-synaptic density (PSD), where they play a critical role in PSD assembly of excitatory synapses during development. While recruitment of SHANK proteins to the synapse is independent of their interaction with Homer, proper synaptic targeting of SHANK1 is mediated by interactions between its PDZ domain and PSD proteins. At the synapse, SHANK proteins interact with NMDA receptors and metabotropic glutamate receptor complexes. Research studies have proposed the involvement of SHANK proteins in autism and neurodegenerative diseases.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
SH3 and multiple ankyrin repeat domains protein 2; Shank2; Cortactin-binding protein 1; CortBP1; Proline-rich synapse-associated protein 1; SHANK2; CORTBP1; KIAA1022; PROSAP1
Swiss Prot
Q9UPX8
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to Human SHANK2.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB:1:500~1:1000 IHC:1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 135 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
SHANK2 polyclonal antibody detects endogenous levels of SHANK2 protein.
Applications Notes
Western blot (WB) analysis of SHANK2 polyclonal antibody at 1:500 dilution LaneA:A549 whole cell lysate LaneB:HCT116 whole cell lysate LaneC:CT26 whole cell lysate LaneD:PC12 whole cell lysate
Host or Source
Rabbit
Available Sizes
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