FR beta polyclonal antibody
Product Specifications
Background
Folate is an essential vitamin that must be obtained from food intake through intestinal absorption in mammals. Folate and reduced folic acid derivatives bind to the folate receptor (FR) family, which mediates the endocytosis of 5-methyltetrahydofolate into the cell. The folate receptors consist of five members, α, β, γ, γ' (which is produced by alternative splicing) and δ. α-FR and β-FR are attached to the membrane by a GPI anchor and are expressed in malignant tissues of epithelial and nonepithelial origin, respectively. γ-FR is expressed in tissues of hematopoietic origin, such as spleen, thymus and bone marrow, but the expression pattern of δ-FR is elusive, which suggests that it is highly restricted both spatially and temporally. α-FR is used as a highly selective tumor marker and may be targeted for the delivery of therapeutic compounds to tumor cells by coupling to derivatives of folic acid.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Folate receptor beta; FR-beta; Folate receptor 2; Folate receptor, fetal/placental; Placental folate-binding protein; FBP; FOLR2
Swiss Prot
P14207
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to Human FR beta.
Conjugation
Unconjugated
Applications
WB
Dilution
WB:1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 35 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
FR beta polyclonal antibody detects endogenous levels of FR beta protein.
Applications Notes
Western blot (WB) analysis of FR beta polyclonal antibody at 1:500 dilution LaneA:HCT116 whole cell lysate LaneB:CT26 whole cell lysate LaneC:PC12 whole cell lysate
Host or Source
Rabbit
Available Sizes
Curated Selection
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