NEIL1 polyclonal antibody

NEIL1, NEIL2 and NEIL3, also known as Endonuclease VIII-like 1, 2 and 3 or DNA- (apurinic or apyrimidinic site) lyase NEIL 1, 2 and 3, are nuclear proteins involved in the repair of DNA damaged by oxidation. The NEIL proteins belong to the FPG familiy of proteins. They act as DNA glycosylases that can recognize and remove damaged bases, leaving an abasic site. NEIL3, however, lacks the proline residue at the N-terminus which acts as the active site residue found in NEIL1 and NEIL2. NEIL1 is a ubiquitiously expressed protein that is upregulated during S phase. NEIL2 is expressed primarily in testis, heart, skeletal muscle, placenta, brain, kidney and liver while NEIL3 is detected primarily in thymus and testis.

Endonuclease 8-like 1; DNA glycosylase/AP lyase Neil1; DNA- (apurinic or apyrimidinic site) lyase Neil1; Endonuclease VIII-like 1; FPG1; Nei homolog 1; NEH1; Nei-like protein 1; NEIL1

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Western blot (WB) analysis of NEIL1 polyclonal antibody at 1:500 dilution LaneA:PC12 whole cell lysate LaneB:AML-12 whole cell lysate LaneC:MCF-7 whole cell lysate LaneD:A549 whole cell lysate