DKK3 polyclonal antibody
Product Specifications
Background
Dickkopf-related protein 3, antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Dickkopf-related protein 3; Dickkopf-3; Dkk-3; hDkk-3; DKK3; REIC; UNQ258; PRO295
Swiss Prot
Q9UBP4
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to Human DKK3.
Conjugation
Unconjugated
Applications
WB
Dilution
WB:1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 55 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
DKK3 polyclonal antibody detects endogenous levels of DKK3 protein.
Applications Notes
Western blot (WB) analysis of DKK3 polyclonal antibody at 1:500 dilution LaneA:Hela whole cell lysate LaneB:A549 whole cell lysate LaneC:C6 whole cell lysate LaneD:The Brain tissue lysate of Mouse
Host or Source
Rabbit
Available Sizes
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