What is the catalog number for CTBP1 polyclonal antibody?

The catalog number for CTBP1 polyclonal antibody is BS62260.

What sizes are available for CTBP1 polyclonal antibody?

CTBP1 polyclonal antibody is available in the following size(s): 50 µL, 100 µL.

How many pack sizes does CTBP1 polyclonal antibody come in?

CTBP1 polyclonal antibody is available in 2 different pack sizes.

Is CTBP1 polyclonal antibody in stock?

CTBP1 polyclonal antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.

What is the immunogen used to generate this antibody?

Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

CTBP1 polyclonal antibody

Product Specifications

Background

CtBP1 is a cellular phosphoprotein that associates with various proteins and functions as a corepressor of transcription. CtBP1 and the related protein CtBP2 are characterized as C-terminal binding protein of adenovirus E1A, and they preferentially associate with the E1A via a 5-amino acid motif, PLDLS, to repress E1A induced oncogenesis and cellular transformation. CtBP1 is expressed from embryo to adult, but CtBP2 is mainly expressed during embryogenesis. During skeletal and T-cell development, CtBP1 and CtBP2 associate with the PLDLSL domain of δEF1, a cellular zinc finger-homeodomain protein, and thereby enhances δEF1 induced transcriptional silencing. In addition, CtBP complexes with CtIP, a protein that recognizes distinctly different protein motifs from CtBP. CtIP binds to the BRCT repeats within the breast cancer gene BRCA1 and enables CtBP to influence BRCA1 activity. CtIP/CtBP binding to BRCA1 inhibits the transactivation of the p21 promoter, and it is critical for regulating p21 transcription in response to DNA damage.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

C-terminal-binding protein 1; CtBP1; CTBP1; CTBP

Swiss Prot

Q13363

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to Human CTBP1.

Conjugation

Unconjugated

Related Pathways

Notch Signaling

Applications

WB IHC IF

Dilution

WB:1:500~1:1000 IHC:1:50~1:200 IF:1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 48 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

CTBP1 polyclonal antibody detects endogenous levels of CTBP1 protein.

Applications Notes

Western blot (WB) analysis of CTBP1 polyclonal antibody at 1:500 dilution LaneA:HEK293T whole cell lysate LaneB:Hela whole cell lysate LaneC:H1688 whole cell lysate LaneD:The Lung tissue lysate of Mouse LaneE:The Kidney tissue lysate of Mouse LaneF:The Lung tissue lysate of Rat LaneG:The Kidney tissue lysate of Rat