NACA1 (Phospho-S43) polyclonal antibody

This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC) . This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Western blot (WB) analysis of NACA1 (Phospho-S43) polyclonal antibody at 1:500 dilution LaneA:HEK293T whole cell lysate LaneB:Jurkat whole cell lysate LaneC:NIH3T3 whole cell lysate LaneD:CT26 whole cell lysate LaneE:H9C2 whole cell lysate LaneF:PC12 whole cell lysate