CD91 (Phospho-S4520) polyclonal antibody
Product Specifications
Background
Musashi1 (Msi1) is an RNA-binding protein expressed in neural progenitor cells and neural stem cells. Msi1 is the mammalian homolog of Drosophila Musashi. The gene encoding human Msi1 encodes a 362 amino acid protein. In murine embryonic neural progenitor cells, Msi1 localizes to the cytoplasm and is downregulated during differentiation. Msi1 binds to NUMB, which encodes a membrane-associated antagonist of Notch signaling. Msi1 appears to function in the proliferation and maintenance of stem cell populations of the central nervous system. In addition to its usefulness as a marker for neural progenitor cells in normal human brains, Msi1 is also a marker for human gliomas. In rats, Msi1 is expressed in Sertoli cells of the testis and granulosa cells of the ovary.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
LRP-1; A2MR; APOER; CD91; LRP1; Msi 1; Msi1; MSI1H; Musashi homolog 1; Musashi-1; Musashi1; RNA binding protein Musashi homolog 1; RNA-binding protein Musashi homolog 1
Swiss Prot
Q07954
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic phosphopeptide derived from human CD91 around the phosphorylation site of Serine 4520.
Conjugation
Unconjugated
Related Pathways
Regulation of Microtubule Dynamics
Applications
WB
Dilution
WB:1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Phosphorylation
Molecular Weight
~ 85 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CD91 (Phospho-S4520) polyclonal antibody detects endogenous levels of CD91 protein only when phosphorylated at Ser4520.
Applications Notes
Western blot (WB) analysis of CD91 (Phospho-S4520) polyclonal antibody at 1:500 dilution LaneA:The Brain tissue lysate of Rat LaneB:C6 whole cell lysate LaneC:L02 whole cell lysate LaneD:HEK293T whole cell lysate
Host or Source
Rabbit
Available Sizes
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