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CD91 (Phospho-S4520) polyclonal antibody

Product Specifications

Background

Musashi1 (Msi1) is an RNA-binding protein expressed in neural progenitor cells and neural stem cells. Msi1 is the mammalian homolog of Drosophila Musashi. The gene encoding human Msi1 encodes a 362 amino acid protein. In murine embryonic neural progenitor cells, Msi1 localizes to the cytoplasm and is downregulated during differentiation. Msi1 binds to NUMB, which encodes a membrane-associated antagonist of Notch signaling. Msi1 appears to function in the proliferation and maintenance of stem cell populations of the central nervous system. In addition to its usefulness as a marker for neural progenitor cells in normal human brains, Msi1 is also a marker for human gliomas. In rats, Msi1 is expressed in Sertoli cells of the testis and granulosa cells of the ovary.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

LRP-1; A2MR; APOER; CD91; LRP1; Msi 1; Msi1; MSI1H; Musashi homolog 1; Musashi-1; Musashi1; RNA binding protein Musashi homolog 1; RNA-binding protein Musashi homolog 1

Swiss Prot

Q07954

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic phosphopeptide derived from human CD91 around the phosphorylation site of Serine 4520.

Conjugation

Unconjugated

Related Pathways

Regulation of Microtubule Dynamics

Applications

WB

Dilution

WB:1:500~1:1000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Phosphorylation

Molecular Weight

~ 85 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

CD91 (Phospho-S4520) polyclonal antibody detects endogenous levels of CD91 protein only when phosphorylated at Ser4520.

Applications Notes

Western blot (WB) analysis of CD91 (Phospho-S4520) polyclonal antibody at 1:500 dilution LaneA:The Brain tissue lysate of Rat LaneB:C6 whole cell lysate LaneC:L02 whole cell lysate LaneD:HEK293T whole cell lysate

Host or Source

Rabbit

Available Sizes

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