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TAK1 (Phospho-T184) polyclonal antibody

Product Specifications

Background

Several serine/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK/MAP kinases, ribosomal S6 kinase (Rsk) and Raf-1. Raf-1 is a protein with intrinsic kinase activity towards serine/threonine residues and that is widely expressed in many tissue types and cell lines. Raf-1 activation is dependent on the small molecular weight GTPase Ras, but the means by which this activation occurs is poorly understood. Two proteins putatively involved in this process are Ksr-1 and Tak1. Ksr-1 (kinase suppressor of Ras) is a novel Raf-related protein kinase whose function is required for Ras signal transduction. Whether Ksr-1 lies directly downstream of Ras or acts in a parallel pathway is not yet known. Tak1 (TGFß-activated kinase) has been shown to participate in the activation of the MAP kinase family in response to TGFß stimulation.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1; MAP3K7; TAK1

Swiss Prot

O43318

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic phosphopeptide derived from human TAK1 around the phosphorylation site of Threonine 184.

Conjugation

Unconjugated

Related Pathways

SAPK JNK Signaling Cascades, G Protein-coupled Receptors Signaling to MAPK Erk, MAPK Erk in Growth and Differentiation Pathway

Applications

WB IHC

Dilution

WB:1:500~1:1000 IHC:1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Phosphorylation

Molecular Weight

~ 70 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

TAK1 (Phospho-T184) polyclonal antibody detects endogenous levels of TAK1 protein only when phosphorylated at Thr184.

Applications Notes

Western blot (WB) analysis of TAK1 (Phospho-T184) polyclonal antibody at 1:500 dilution LaneA:The Muscle tissue lysate of Mouse

Host or Source

Rabbit

Available Sizes

Frequently Asked Questions

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