CPD polyclonal antibody

Product Specifications

Background

Members of the M14 metallocarboxypeptidase protein family serve many diverse functions and are divided into three subfamilies based on structure, function and amino acid sequence similarity. CPD (carboxypeptidase D), also known as GP180 or metallocarboxypeptidase D, is a 1,380 amino acid single-pass type I membrane protein that belongs to the peptidase M14 family. CPD binds two zinc ions per subunit and contains three carboxypeptidase-like domains. CPD causes the release of C-terminal arganine and lysine from polypeptides. Highest expression of CPD is found in pancreas, hepatoma cells and placenta, with lower levels in heart, skeletal muscle and colon carcinoma. Mammalian CPD is a homolog of the duck hepatitis B virus-binding protein gp180.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Carboxypeptidase D; Metallocarboxypeptidase D; gp180; CPD

Swiss Prot

O75976

Reactivity

Human

Immunogen

A synthetic peptide corresponding to residues in Human CPD.

Conjugation

Unconjugated

Applications

Dilution

WB: 1:500~1:1000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .