Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Bax (Phospho-Ser184) polyclonal antibody

Product Specifications

Background

The protein encoded by BAX (BCL2 associated X, apoptosis regulator) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for BAX.

CAS Number

9007-83-4

Structure Composition

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Product Name Alternative

BAX; BCL2L4; Apoptosis regulator BAX; Bcl-2-like protein 4; Bcl2-L-4

Swiss Prot

Q07812

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human Bax around the phosphorylation site of Ser184. AA range:143-192

Conjugation

Unconjugated

Related Pathways

Regulation of Apoptosis, SAPK JNK Signaling Cascades

Applications

IHC-p, IF (paraffin section), ELISA

Dilution

Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Modification

Phosphorylation

Molecular Weight

/

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Phospho-Bax (S184) Polyclonal Antibody detects endogenous levels of Bax protein only when phosphorylated at S184.

Applications Notes

Immunohistochemistry analysis of paraffin-embedded human brain, using Bax (Phospho-Ser184) Antibody. The picture on the right is blocked with the phospho peptide.

Host or Source

Rabbit

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Recombinant (Sf9) HumanHistidyl-tRNA Synthetase
RP-416 2 µg

Recombinant (Sf9) HumanHistidyl-tRNA Synthetase

Ask
View Details
Phospho-Nanog(S71) Antibody Blocking peptide
MBS9225212-01 0.5 mg

Phospho-Nanog(S71) Antibody Blocking peptide

Ask
View Details
Phospho-Nanog(S71) Antibody Blocking peptide
MBS9225212-02 5x 0.5 mg

Phospho-Nanog(S71) Antibody Blocking peptide

Ask
View Details
ME2 (NM_002396) Human Over-expression Lysate
LC419348 20 µg

ME2 (NM_002396) Human Over-expression Lysate

Ask
View Details
IMMP1L Antibody
E19-9629-2 100 µg -100 µL

IMMP1L Antibody

Ask
View Details
Human Procollagen II N-Terminal Propeptide (PIINP) ELISA Kit
BSKH61221-01 48 Tests

Human Procollagen II N-Terminal Propeptide (PIINP) ELISA Kit

Ask
View Details