Phospho-LRP6 (Thr1479) Polyclonal Antibody
Product Specifications
Background
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined
CAS Number
9007-83-4
Structure Composition
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Product Name Alternative
LRP6 (Phospho-Thr1479) ; LRP6 (Phospho-T1479) ; p-LRP6 (Thr1479) ; p-LRP6 (T1479) ; ADCAD2; C030016K15Rik; Cd; FLJ90062; FLJ90421; Low density lipoprotein receptor related protein 6; LRP6_HUMAN; Low-density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6 precursor; LRP-6.
Swiss Prot
O75581
Reactivity
Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig
Conjugation
Unconjugated
Related Pathways
Regulation of Microtubule Dynamics
Applications
FCM
Dilution
Flow-Cyt=0.2ug/test
Purity
Affinity purified by Protein A
Modification
Phosphorylation
Molecular Weight
175kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Phospho-LRP6 (Thr1479) Polyclonal Antibody detects endogenous levels of LRP6 protein only when phosphorylated at Thr1479.
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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