CHRDL2 Polyclonal Antibody
Product Specifications
Background
CHRDL2 is a novel chordin like protein that can act as a BMP antagonist. A member of the chordin family of proteins, it contains a signal peptide and three CR (cysteine-rich repeat) domains. When expressed as a recombinant protein it is secreted and binds to activin A, but not to BMP-2, -4, -6. Differential expression has been detected in developing chondrocytes, myoblasts, osteoblasts, and osteoarthritic joints. Complex alternative splicing of CHRDL2 potentially results in distinct isoforms that differ at their C termini, in the expression of signal peptide, and in the content of CR domains. CHRDL2 was originally characterized as a novel protein exclusively expressed in breast, lung, and colon tumors.
CAS Number
9007-83-4
Structure Composition
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Product Name Alternative
BNF1; Breast tumor novel factor 1; CHL2; chordin like 2; Chordin like protein 2 precursor; Chordin related protein 2; CRDL2_HUMAN.
Swiss Prot
Q6WN34
Reactivity
Human, Mouse, Rat, Cow, Sheep
Immunogen
KLH conjugated synthetic peptide derived from human CHRDL2:351-429/429
Conjugation
Unconjugated
Applications
WB
Dilution
WB=1:500-2000
Purity
Affinity purified by Protein A
Modification
Unmodification
Molecular Weight
~45kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -45°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CHRDL2 Polyclonal Antibody detects endogenous levels of CHRDL2 protein.
Applications Notes
Primary: Anti- CHRDL2 at 1/1000 dilution
Host or Source
Rabbit
Available Sizes
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