PAFR/PAF Receptor Polyclonal Antibody
Product Specifications
Background
The PAF receptor binds platelet-activating factor (PAF) and is thought to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. PAF is a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. It has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.The PAF receptor is induced by granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin-5 and n-butyrate. A diverse range of compounds act as PAF receptor antagonists; these may be useful pharmacologically.
CAS Number
9007-83-4
Structure Composition
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Product Name Alternative
Platelet-activating factor receptor; PAF receptor; Ptafr; OTTHUMP00000004041; OTTMUSP00000010350; PAF R; PAF-R; PAFR; Platelet activating factor receptor; Platelet-activating factor receptor; PTAFR; PTAFR_HUMAN; RP23-470B20.1.
Swiss Prot
P25105
Reactivity
Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit
Immunogen
KLH conjugated synthetic peptide derived from human PAFR:231-342/342
Conjugation
Unconjugated
Applications
WB, IHC-P
Dilution
WB=1:500-2000, IHC-P=1:100-500
Purity
Affinity purified by Protein A
Modification
Unmodification
Molecular Weight
38kD
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
PAFR/PAF Receptor Polyclonal Antibody detects endogenous levels of PAFR/PAF Receptor protein.
Applications Notes
Primary: Anti-PTAFR at 1:200 dilution
Host or Source
Rabbit
Available Sizes
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