COQ10B Polyclonal Antibody
Product Specifications
Background
COQ10B, Coenzyme Q10, is a 247 amino acid protein encoded by the human gene COQ10B. COQ10B is a mitochondrial protein that belongs to the COQ10 family. COQ10B is an essential biological cofactor which increases brain mitochondrial concentration and exerts neuroprotective effects. Plasma COQ10B levels decrease in patients with advanced chronic heart failure (CHF) while COQ10B levels in hyperthyroid patients are found among the lowest detected in human diseases. Likewise, COQ10B is elevated in hypothyroid subjects, also in subclinical conditions, suggesting the usefulness of this index in assessing metabolic status in thyroid disorders. It is believed that secretion of adrenal hormones is in some way related to COQ10B levels, both in augmented and reduced conditions. However, since thyroid hormones have an important role in modulating COQ10B levels and metabolism, when coexistent, thyroid deficiency seems to play a prevalent role in comparison with adrenal deficiency.
CAS Number
9007-83-4
Structure Composition
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Product Name Alternative
Coenzyme Q10; Coenzyme Q10 B; Coenzyme Q10 homolog B; Coenzyme Q10B; CQ10B_HUMAN.
Swiss Prot
Q9H8M1
Reactivity
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Orangutan
Immunogen
KLH conjugated synthetic peptide derived from human COQ10B:38-110/238
Conjugation
Unconjugated
Applications
WB
Dilution
WB=1:500-2000
Purity
Affinity purified by Protein A
Modification
Unmodification
Molecular Weight
26 kD, 23 kD, 25 kD
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
COQ10B Polyclonal Antibody detects endogenous levels of COQ10B protein.
Applications Notes
Primary: Anti- COQ10B at 1/1000 dilution
Host or Source
Rabbit
Available Sizes
Curated Selection
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