Caspr2 Polyclonal Antibody
Product Specifications
Background
CASPR is a transmembrane glycoprotein of the neurexin superfamily that is highly enriched in regions of myelinated axons. The axons of myelinated nerves in the adult nervous system possess specialized subcellular structures essential for efficient and rapid action potential propagation. CASPR and the closely related molecule CASPR2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), demarcate distinct subdomains in myelinated axons. While CASPR is present at the paranodal junctions, CASPR2 is precisely colocalized with Shaker-like K+ channels in the juxtaparanodal region. CASPR2 specifically associates with Kv1.1, Kv1.2, and their Kvbeta2 subunit. CASPR family members may play a role in the local differentiation of the axon into distinct functional subdomains.
CAS Number
9007-83-4
Structure Composition
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Product Name Alternative
Cell recognition molecule Caspr2; Cntnap2; CNTP2; CNTP2_HUMAN; Contactin-associated protein-like 2.
Swiss Prot
Q9UHC6
Reactivity
Human, Rat
Immunogen
KLH conjugated synthetic peptide derived from human Caspr2
Conjugation
Unconjugated
Applications
FCM
Dilution
Flow-Cyt=1ug/Test
Purity
Affinity purified by Protein A
Modification
Unmodification
Molecular Weight
145kD
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Caspr2 Polyclonal Antibody detects endogenous levels of Caspr2 protein.
Host or Source
Rabbit
Available Sizes
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