SUR1 Polyclonal Antibody
Product Specifications
Background
SUR1 is a member of ATP binding cassette super family. SUR receptor confers the sensitivity of Kir6.2 to ATP/ADP sensitivity and to pharmacological agents such as sulfonylurea and diazoxide that close or open the KATP channels. The persistent heyperinsulinimic hypoglycemia in infancy (PHHI) is familial disorder due to defect in negative feed back in response to low glucose levels. SUR1 was mapped on chromosome 11p14-15.1, the same location where the gene for PHHI is located. It has been shown that the expression of Kir6.2 and SUR1 are regulated by glucose levels and the actives of glucogon like peptide receptor 1. Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene.
CAS Number
9007-83-4
Structure Composition
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Product Name Alternative
ABC36; Abcc8; ATP binding cassette sub family C (CFTR/MRP) member 8; ATP binding cassette transporter sub family C member 8 (1) ; HHF1; HRINS; MRP8; PHHI; Sulfonylurea receptor 1; SUR.
Swiss Prot
Q09428
Reactivity
Human, Mouse, Rat, Dog, Pig, Horse, Guinea Pig
Immunogen
KLH conjugated synthetic peptide derived from human SUR1
Conjugation
Unconjugated
Applications
WB
Dilution
WB=1:500-2000
Purity
Affinity purified by Protein A
Modification
Unmodification
Molecular Weight
175 kD
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
SUR1 Polyclonal Antibody detects endogenous levels of SUR1 protein.
Applications Notes
Sample: Hippocampus (Mouse) Lysate at 40 ug Primary: Anti-SUR1 at 1/1000 dilution
Host or Source
Rabbit
Available Sizes
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