What is the catalog number for Phospho-p53BP1 (Ser25 + Ser29) Polyclonal Antibody?

The catalog number for Phospho-p53BP1 (Ser25 + Ser29) Polyclonal Antibody is BS65621.

What sizes are available for Phospho-p53BP1 (Ser25 + Ser29) Polyclonal Antibody?

Phospho-p53BP1 (Ser25 + Ser29) Polyclonal Antibody is available in the following size(s): 50 µL, 100 µL.

How many pack sizes does Phospho-p53BP1 (Ser25 + Ser29) Polyclonal Antibody come in?

Phospho-p53BP1 (Ser25 + Ser29) Polyclonal Antibody is available in 2 different pack sizes.

Is Phospho-p53BP1 (Ser25 + Ser29) Polyclonal Antibody in stock?

Phospho-p53BP1 (Ser25 + Ser29) Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Phospho-p53BP1 (Ser25 + Ser29) Polyclonal Antibody

Product Specifications

Background

P53 binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double strand breaks. This also suggests a role in DNA repair, maintaining genomic stability.

CAS Number

9007-83-4

Structure Composition

0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Product Name Alternative

53BP1 (phospho S25) ; p-53BP1 (phospho S25) ;53BP1 (Phospho-Ser25/29) ; 53BP1 (Phospho-S25/S29) ; phospho-p53BP1 (Ser25/Ser29) ; P-53BP1 (Ser25/29) ; 53 BP1; FLJ41424; MGC138366; p202; p53 binding protein 1; p53 BP1; p53BP1; TP53 BP1; TP53BP1; Tumor protein 53 binding protein 1; Tumor protein p53 binding protein 1; Tumor suppressor p53 binding protein 1; TP53B_HUMAN; tumor protein 53-binding protein, 1.

Swiss Prot

Q12888

Reactivity

Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit

Immunogen

KLH conjugated Synthesised phosphopeptide derived from human p53BP1 around the phosphorylation site of Ser25/29:ED (p-S) QPE (p-S) QV

Conjugation

Unconjugated

Related Pathways

Cell Cycle G2 M DNA Damage Signaling Pathway

Applications

IHC-P

Dilution

IHC-P=1:100-500

Purity

Affinity purified by Protein A

Modification

Phosphorylation

Molecular Weight

213kD

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Phospho-p53BP1 (Ser25 + Ser29) Polyclonal Antibody detects endogenous levels of phospho-p53BP1 protein only when phosphorylated at Ser25 + Ser29.

Applications Notes

Paraformaldehyde-fixed, paraffin embedded (Rat brain) ; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (phospho-p53BP1 (Ser25 + Ser29) ) Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C