PITX3 polyclonal antibody
Product Specifications
Background
The transcription factor PITX3 is expressed selectively in the midbrain and regulates the differentiation and survival of dopaminergic neurons. Lack of this factor results in a degeneration similar to that seen in Parkinson's disease. PITX3 is also important in eye developement; mutations of the PITX3 gene have been associated with a familial form of cataracts.
CAS Number
9007-83-4
Structure Composition
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Product Name Alternative
Homeobox protein PITX 3; Homeobox protein PITX3; MGC12766; Paired like homeodomain transcription factor 3; Paired-like homeodomain transcription factor 3; Pituitary homeobox 3; PITX 3; Pitx3; PITX3_HUMAN; PTX 3; PTX3.
Swiss Prot
O75364
Reactivity
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit
Immunogen
KLH conjugated synthetic peptide derived from human PITX3:231-302/302
Conjugation
Unconjugated
Applications
IHC-P
Dilution
IHC-P=1:100-500 () not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Purity
Affinity purified by Protein A
Modification
Unmodification
Molecular Weight
~32kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
PITX3 polyclonal Antibody detects endogenous levels of PITX3 protein.
Applications Notes
Paraformaldehyde-fixed, paraffin embedded (Mouse brain) ; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PITX3) Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C.
Host or Source
Rabbit
Available Sizes
Curated Selection
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