DEPTOR polyclonal antibody

Product Specifications

Background

DEPTOR (DEP domain containing MTOR-interacting protein), also known as DEP.6 or DEPDC6 (DEP domain-containing protein 6), is a 409 amino acid protein that negatively regulates mTORC1 and mTORC2 pathways. DEPTOR interacts with FRAP via its PDZ domain, and undergoes post-translational phosphorylation. Containing two DEP domains and one PDZ (DHR) domain, DEPTOR is encoded by a gene that maps to human chromosome 8q24.12. Chromosome 8 consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8.

CAS Number

9007-83-4

Structure Composition

0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Product Name Alternative

DEP domain containing 6; DEP domain-containing mTOR-interacting protein; DEP domain-containing protein 6; DEPDC6; DEPTOR; DPTOR_HUMAN.

Swiss Prot

Q8TB45

Reactivity

Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit

Immunogen

KLH conjugated synthetic peptide derived from human DEPTOR:151-250/409

Conjugation

Unconjugated

Related Pathways

Phosphoinosotode Signaling, Glutamine Metabolism

Applications

Dilution

WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

Purity

Affinity purified by Protein A

Modification

Unmodification

Molecular Weight

~49kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

DEPTOR polyclonal Antibody detects endogenous levels of DEPTOR protein.

Applications Notes

Anti- DEPTOR at 1/1000 dilution

Host or Source

Rabbit

Available Sizes

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