Cyclophilin B monoclonal Antibody
Product Specifications
Background
The cyclophilins are a conserved class of proteins that bind the immunosuppressive drug cyclosporin A (CsA) with high affinity. CsA blocks helper T-cell activation at a step between T-cell receptor stimulation and the transcriptional activation of cytokine genes. Cyclophilins from many species possess peptidyl-prolyl cis-trans isomerase (PPIase) activity that is blocked by CsA and therefore may be relevant in CsA-mediated immunosuppression.
CAS Number
9007-83-4
Structure Composition
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Product Name Alternative
Cphn 2; Cphn2; CyP 20b; CYP S1; CYP-S1; CYPB; MGC14109; MGC2224; peptidyl prolyl cis trans isomerase B; Peptidyl prolyl cis trans isomerase B precursor; Peptidyl-prolyl cis-trans isomerase B precursor; Peptidylprolyl isomerase B; PPIase; PPIB; Rotamase; S cyclophilin; SCYLP; PPIB_HUMAN.
Swiss Prot
P23284
Reactivity
Human, Mouse, Rat
Immunogen
KLH conjugated synthetic peptide derived from human Cyclophilin B
Conjugation
Unconjugated
Applications
WB
Dilution
WB=1:1000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Purity
Affinity purified by Protein G
Modification
Unmodification
Molecular Weight
~20 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Cyclophilin B monoclonal Antibody detects endogenous levels of Cyclophilin B protein.
Applications Notes
Western blot (WB) analysis of Cyclophilin B monoclonal antibody at 1:1000 dilution.
Host or Source
Mouse
Available Sizes
Curated Selection
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