What is the catalog number for JAK2 polyclonal antibody?

The catalog number for JAK2 polyclonal antibody is BS90749.

What sizes are available for JAK2 polyclonal antibody?

JAK2 polyclonal antibody is available in the following size(s): 50 µL, 100 µL.

How many pack sizes does JAK2 polyclonal antibody come in?

JAK2 polyclonal antibody is available in 2 different pack sizes.

Is JAK2 polyclonal antibody in stock?

JAK2 polyclonal antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.

JAK2 polyclonal antibody

Product Specifications

Background

JAK2 (Janus kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK2. JAK2 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

JAK-2; JAK2; Janus Activating Kinase 2; Janus kinase 2 (a protein tyrosine kinase) ; Janus kinase 2; ; JTK10; kinase Jak2; OTTHUMP00000043260; THCYT3; Tyrosine protein kinase JAK2; Tyrosine-protein kinase JAK2

Swiss Prot

O60674

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein.

Conjugation

Unconjugated

Applications

WB IF

Dilution

WB:1:2000~1:5000 IF: 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 130 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

JAK2 polyclonal antibody detects endogenous levels of JAK2 protein.

Applications Notes

Western blot (WB) analysis of JAK2 pAb at 1:2000 dilution Lane1:Hela whole cell lysate (40ug) Lane2:U-87MG whole cell lysate (40ug) Lane3:AML-12 whole cell lysate (40ug) Lane4:H9C2 whole cell lysate (40ug)