SGK (S422) polyclonal antibody
Product Specifications
Background
Serum and glucocorticoid-inducible kinase (SGK) is a serine/threonine kinase closely related to Akt. SGK is rapidly induced in response to a variety of stimuli, including serum, glucocorticoid, follicle stimulating hormone, osmotic shock, and mineralocorticoids. SGK activation can be accomplished via HGF PI3K-dependent pathways and by integrin-mediated PI3K-independent pathways. Induction and activation of SGK has been implicated in activating the modulation of anti-apoptotic and cell cycle regulation. SGK also plays an important role in activating certain potassium, sodium, and chloride channels, suggesting its involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. SGK is negatively regulated by ubiquitination and proteasome degradation.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Serine/threonine-protein kinase Sgk1; Serum/glucocorticoid-regulated kinase 1; SGK1; SGK; Serine/threonine-protein kinase Sgk2Serum/glucocorticoid-regulated kinase 2; SGK2; Serine/threonine-protein kinase Sgk3; Cytokine-independent survival kinase; Serum/glucocorticoid-regulated kinase 3; Serum/glucocorticoid-regulated kinase-like; SGK3; CISK; SGKL
Swiss Prot
O00141/Q9HBY8/Q96BR1
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide, corresponding to Human SGK.
Conjugation
Unconjugated
Related Pathways
MTOR signaling
Applications
WB
Dilution
WB: 1:2000~1:5000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 58 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
SGK (S422) polyclonal antibody detects endogenous levels of SGK protein.
Applications Notes
Western blot (WB) analysis of SGK (S422) polyclonal antibody at 1:2000 dilution Lane1:Hela whole cell lysate (40ug) Lane2:PC3 whole cell lysate (40ug) Lane3:HEK293T whole cell lysate (40ug) Lane4:BV2 whole cell lysate (40ug) Lane5:PC12 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
Curated Selection
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