ATRIP polyclonal antibody
Product Specifications
Background
The product of the ATRIP gene is an essential component of the DNA damage checkpoint, and binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage. The encoded protein interacts with the ataxia telangiectasia and Rad3 related protein, a checkpoint kinase, resulting in accumulation of the kinase at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
ATR-interacting protein; ATM and Rad3-related-interacting protein; ATRIP; AGS1
Swiss Prot
Q8WXE1
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to Human ATRIP.
Conjugation
Unconjugated
Applications
WB IHC IF ICC
Dilution
WB 1:500 - 1:1000 IHC 1:50 - 1:200 IF 1:50 - 1:200 ICC 1:50 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 95 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
ATRIP polyclonal antibody detects endogenous levels of ATRIP protein.
Applications Notes
Western blot analysis of ATRIP expression in Jurkat (A) whole cell lysates.
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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