IgG4 Rabbit monoclonal antibody

The regions of relatively constant sequence beyond the variable regions of immunoglobulins are termed constant regions (C regions) and are present in both the heavy and light chains. With very few exceptions, the sites of attachment for carbohydrates on immunoglobulins are located in these C regions. These regions also function to hold the variable regions together by using the disulfide bond between them. The C regions facilitate interaction with the antigen by increasing the maximum rotation of the immunoglobulin arms. Several studies have shown that a large population of patients with recurrent respiratory tract infection have low IgG4 concentrations.

AU044919; Gamma 2b immunoglobulin; Ig gamma 4 chain C region; Ighg 4; Ighg4; Immunoglobulin gamma 4 heavy chain; Immunoglobulin heavy chain (gamma polypeptide 4) ; Immunoglobulin heavy chain gamma polypeptide; Immunoglobulin heavy constant gamma 4 (G4m marker) ; MGC102604; MGC102659

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .