SAT1 polyclonal antibody
Product Specifications
Background
Spermidine/spermine N1-acetyltransferase 1 (SAT1) is a key enzyme in polyamine metabolism. It acts by acetylating spermidine and spermine using acetyl-coenzyme A (CoA), which alters their charge and facilitates their secretion. SAT1 activity is tightly controlled in cells, but increases quickly by excess polyamines. Its activity can also be induced by a number of other stimuli, such as oxidative stress, heat shock, insulin-like growth factor-I, and cytotoxins. Research studies have found that SAT1 is overexpressed in glioblastoma multiforme (GBM), which suggest that SAT1 may be a potential therapeutic target for GBM.
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
SAT; Diamine acetyltransferase 1; Polyamine N-acetyltransferase 1; Putrescine acetyltransferase; Spermidine/spermine N (1) -acetyltransferase 1; SSAT; SSAT-1
Swiss Prot
P21673
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human SAT1. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/2000)
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 23 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of SAT1 protein
Applications Notes
Western blot analysis of SAT1 expression in THP1 (A) whole cell lysates.
Host or Source
Rabbit
CAS Number
9007-83-4
Available Sizes
Curated Selection
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