Kinectin 1 polyclonal antibody
Product Specifications
Background
Kinectin 1 (KTN1) is an endoplasmic reticulum (ER) -enriched integral membrane protein that may be involved in the formation of ER sheets (reviewed in 1) . Kinectin 1 binds the microtubule motor protein kinesin and acts as a membrane anchor for kinesin-based organelle trafficking. The interaction of kinesin with kinectin 1 has been shown to affect ER-supported focal adhesion assembly. Kinectin 1 has also been implicated in translation elongation, as an anchor for the elongation factor complex to the ER. Research investigators have shown that kinectin 1 expression is altered in multiple human pathologies, including breast cancer, hepatocellular carcinoma (HCC), Parkinson's disease , and the autoimmune syndrome Behçet's disease (BD)
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
CG1; KIAA0004; Kinectin; CG-1 antigen; Kinesin receptor
Swiss Prot
Q86UP2
Reactivity
Human, Mouse
Immunogen
KLH-conjugated synthetic peptide of human Kinectin 1
Conjugation
Unconjugated
Applications
WB, IHC
Dilution
WB (1/500 - 1/2000), IHC (1/50 - 1/200)
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 160 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of Kinectin 1 protein.
Applications Notes
Western blot analysis of Kinectin 1 expression in K562 (A), mouse testis (B) whole cell lysates.
Host or Source
Rabbit
Available Sizes
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