HAO1 polyclonal antibody

Product Specifications

Background

Broad substrate specificity (S) -2-hydroxy-acid oxidase that preferentially oxidizes glycolate.The glyoxylate produced by the oxidation of glycolate can then be utilized by alanine-glyoxylate aminotransferase for the peroxisomal synthesis of glycine; this pathway appears to be an important step for the detoxification of glyoxylate which, if allowed to accumulate, may be metabolized to oxalate with formation of kidney stones.Can also catalyze the oxidation of glyoxylate, and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, albeit with much lower catalytic efficiency.Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2.Is not active on L-lactate and 2-hydroxybutanoate.

CAS Number

9007-83-4

Structure Composition

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Product Name Alternative

GOX1; HAOX1; Hydroxyacid oxidase 1; HAOX1; Glycolate oxidase; GOX

Swiss Prot

Q9UJM8

Reactivity

Human, Mouse

Immunogen

Recombinant full length protein of human HAO1

Conjugation

Unconjugated

Applications

WB, IHC

Dilution

WB (1/500 - 1/2000), IHC (1/50 - 1/200)

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .