HAO1 polyclonal antibody
Product Specifications
Background
Broad substrate specificity (S) -2-hydroxy-acid oxidase that preferentially oxidizes glycolate.The glyoxylate produced by the oxidation of glycolate can then be utilized by alanine-glyoxylate aminotransferase for the peroxisomal synthesis of glycine; this pathway appears to be an important step for the detoxification of glyoxylate which, if allowed to accumulate, may be metabolized to oxalate with formation of kidney stones.Can also catalyze the oxidation of glyoxylate, and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, albeit with much lower catalytic efficiency.Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2.Is not active on L-lactate and 2-hydroxybutanoate.
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
GOX1; HAOX1; Hydroxyacid oxidase 1; HAOX1; Glycolate oxidase; GOX
Swiss Prot
Q9UJM8
Reactivity
Human, Mouse
Immunogen
Recombinant full length protein of human HAO1
Conjugation
Unconjugated
Applications
WB, IHC
Dilution
WB (1/500 - 1/2000), IHC (1/50 - 1/200)
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~40 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of HAO1 protein.
Applications Notes
Western blot analysis of HAO1 expression in mouse liver (A), rat liver (B) whole cell lysates.
Host or Source
Rabbit
Available Sizes
Curated Selection
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