HMGCR polyclonal antibody
Product Specifications
Background
Catalyzes the conversion of (3S) -hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis.HMGCR is the main target of statins, a class of cholesterol-lowering drugs.
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase
Swiss Prot
P04035
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant full length protein of human HMGCR
Conjugation
Unconjugated
Applications
WB, IHC, IF/ICC
Dilution
WB (1/500 - 1/2000), IHC (1/50 - 1/200), IF/ICC (1/50 - 1/200)
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~115 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of HMGCR protein.
Applications Notes
Western blot analysis of HMGCR expression in HepG2 (A), Hela (B), mouse spleen (C), rat liver (D) whole cell lysates.
Host or Source
Rabbit
Available Sizes
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