Cytokeratin 10 monoclonal antibody
Product Specifications
Background
Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) assemble to form filaments (1,2) . Keratin isoforms demonstrate tissue- and differentiation-specific profiles that make them useful as research biomarkers . Research studies have shown that mutations in keratin genes are associated with skin disorders, liver and pancreatic diseases, and inflammatory intestinal diseases
CAS Number
9007-83-4
Structure Composition
Mouse IgG3. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.
Product Name Alternative
KPP; Keratin type I cytoskeletal 10; Cytokeratin-10; CK-10; Keratin-10; K10
Swiss Prot
P13645
Reactivity
Human
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within human Cytokeratin 10. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
IHC
Dilution
IHC (1/100 - 1/300)
Purity
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 58 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of Cytokeratin 10 protein.
Host or Source
Mouse
Available Sizes
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