PI3K p110 alpha monoclonal antibody

Product Specifications

Background

This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K) . These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB) . PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011].

CAS Number

9007-83-4

Structure Composition

Mouse IgG3. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.

Product Name Alternative

Phosphatidylinositol 45-bisphosphate 3-kinase catalytic subunit alpha isoform; PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; Phosphatidylinositol 45-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Serine/threonine protein kinase PIK3CA

Swiss Prot

P42336

Reactivity

Human

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within human PI3K p110 alpha. The exact sequence is proprietary.

Conjugation

Unconjugated

Related Pathways

Phosphoinosotode Signaling, PI3K AKT signaling, Protein Kinase C Signaling, Warburg Effect, Tumor Angiogenesis, Translational Contral elF4 and p70 S6 Kinase, SAPK JNK Signaling Cascades, Inhibition of Apoptosis, Insulin &Glucose Signaling, G Protein-coupled Receptors Signaling to MAPK Erk, Adherens Junction signaling, Mitochondrial Control of Apoptosis, MTOR signaling

Applications

WB, IHC, IF

Dilution

WB (1/500 - 1/1000), IHC (1/100 - 1/300), IF (1/100 - 1/500)

Purity

The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .